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Why is this drug prescribed?

Xenical blocks absorption of dietary fat into the bloodstream, thereby reducing the number of calories you get from a meal. At the usual dosage level, it cuts fat absorption by almost one-third. Combi ned with a low-calorie diet, it is used to promote weight loss and discourage the return of unwanted pounds.

The drug is prescribed for the frankly obese and for merely overweight people who have other health problems such as high blood pressure, diabetes, or high cholesterol levels. Your weight status is determined by your body mass index (BMI), a comparison of height to weight.

How should you take this medication?

Xenical prevents the absorption of some of the fat you eat. Therefore, you should take it during the meal or within 1 hour of eating. If you occasionally miss a meal or eat a meal that contains no fat , you should skip the dose of Xenical.

Because Xenical may decrease the amount of some vitamins that your body can absorb from food, you will need to take a multivitamin supplement once a da y. Take the vitamin supplement at least 2 hours before or after taking Xenical

special dietary instructions

Follow the diet program your doctor has given you. You should evenly divide your daily intake of fat, carbohydrates, and protein over three main meals. If Xenical is taken with a meal very high in fat (30% total daily calories from fat), you may experience more side effects from the medication.

Xenical blocks your body's uptake of some fat-soluble vitamins and beta carotene. Therefore, wh en you use Xenical you should take a daily multivitamin supplement that contains vitamins A, E, K, and beta-carotene. Take the vitamin once a day, 2 hours before or 2 hours after taking Xenical, or ta ke the vitamin at bedtime.

Possible food and drug interactions

If Xenical is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Xenical with the fo llowing:

- Cyclosporine (Neoral and Sandimmune)
- Warfarin (Coumadin)

Possible Side Effect

Weight loss begins within 2 weeks and continues for 6 to 12 months. The effect of using Xenical for more than 2 years is still unknown.

Side effects such as diarrhea and abdominal pain may b e worse if you continue eating a high fat diet or even take a high-fat meal. Limit your fat intake.

Your doctor will test your thyroid function before starting you on Xenical to make sure th at your weight problem is not due to an underactive thyroid gland (hypothyroidism). Xenical is not an appropriate remedy for this problem.

Xenical increases the likelihood of kidney stones. Use it with caution if you have a history of this problem.

If you have diabetes, weight-loss is likely to reduce your blood sugar levels.

Precautions while Using this Medicine

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.

For patients with diabetes: Weight loss may result in an improvement in your condition, and your doctor may need to change your dose of oral diabetes medicine or insulin.


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