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Other Medicines
When you are taking Zyban, it is especially important that your health care professional know if you are taking any of the following:
- Tricyclic antidepressants (amitriptyline [e.g., Elavil
], amoxapine [e.g., Asendin], clomipramine [e.g., Anafranil], desipramine [e.g., Pertofrane], doxepin [e.g., Sinequan], imipramine [e.g., Tofranil], nortriptyline [e.g., Aventyl], protriptyline [e.g.,
Vivactil], trimipramine [e.g., Surmontil]) or
-
- Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegi
line [e.g., Eldepryl], tranylcypromine [e.g., Parnate])¡X Do not take Zyban while you are taking or within 14 days of taking an MAO inhibitor
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What special precautions should I follow?
Your doctor should check your progress at regular visits, especially during the first few months of treatment with this medicine. The amount of Zyban you take may have to be changed often to meet the
needs of your condition and to help avoid unwanted effects.
Do not take Zyban within 14 days of taking an MAO inhibitor.
Zyban is sold under different brand names for different uses.
If you are already taking medicine for mental depression or to help you stop smoking, discuss this with your health care professional before taking Zyban. It is very important that you receive only o
ne prescription for Zyban at a time.
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What is this Drug
3 Zyban (Wellbutrin SRR, ZybanR)
Approved indication: 1) Symptomatic relief of depressive illness (effectiveness for use > 8 weeks has not been evaluated in controlled trials). 2) As an aid to smo
king cessation (6-7 weeks).
Mechanism of action: Zyban is chemically related to sympathomimetic drugs and unrelated to other antidepressants. It blocks reuptake of noradrenaline and dopamine,
but the mechanism for its clinical effects is unknown.
Pharmacokinetics: It is extensively metabolized by the liver to at least 3 active metabolites. Half-life of parent drug and active meta
bolites is 20 to 37 hrs.
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What side effects can this medication cause?
Less common side effects may include:
Abnormal thinking, allergic reaction, bronchitis, changes in taste, difficulty breathing, dry skin, fever, hives, hot flashes, increased appetite or loss of
appetite, increased blood pressure, migraine, mouth ulcers, muscle pain, neck pain, nosebleed, ringing in the ears, shakiness, sinus inflammation, sleepiness, throbbing heartbeat
Rare side ef
fects may include:
Chest pain, feeling of unhappiness, thirst, swelling of the face
If you are using the oral concentrate form of Zoloft, do not take disulfiram (Antabuse)
If you ar
e using the oral concentrate form of Zoloft, do not take disulfiram (Antabuse)
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Symptoms of overdose
Fast heartbeat; hallucinations (seeing, hearing, or feeling things that are not there); loss of consciousness ; nausea; seizures (convulsions) ; vomiting
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Precautions Before Using This Medicine
Zyban has not been tested in pregnant women. If you are pregnant or plan to become pregnant, do your best to quit smoking with the aid of counseling and support before turning to drug therapy. For the
sake of the baby, you should avoid smoking or taking nicotine in any other form while pregnant.
Zyban appears in breast milk and could affect a nursing infant. Ask your doctor whether it wi
ll be better to discontinue the medication or to stop breastfeeding.
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